Iron Oxides Nanoparticles as Components of Ferroptosis-Inducing Systems: Screening of Potential Candidates

This study presents an analysis of a set iron oxides nanoparticles (NPs) (γ-Fe2O3, α-FeOOH, δ-FeOOH, 5Fe2O3·9H2O, and Fe3O4) as potential candidates for ferroptosis therapy in terms phase state, magnetic characteristics, the release Fe2+/Fe3+ ROS mediators. Due to values saturation magnetization Fe3O4 (31.6 emu/g) γ-Fe2O3 (33.8 emu/g), well surface area these particles (130 123 m2/g), it is possible consider them promising magnetically controlled carriers that can function with various ligands. The evaluation ions catalysts Fenton reaction showed concentration released increases within first 3 h after suspension decreases 24 h, which probably indicates desorption adsorption from/onto regardless their nature. by all nanoparticles, except α-FeOOH-Fe2+, reached 9.1 mg/L Fe3+ 1.7 Fe2+, makes preferable controlling catalysis reaction. In contrast, high 90 316 Fe2+ from compound α-FeOOH-Fe2+ allows us utilize this oxide aid agent. Results obtained on will provide data most prospective are used ferroptosis-inducing systems.